Blar i forfatter "Hansen, John Bjarne"

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    • C1 inhibitor deficiency enhances contact pathway–mediated activation of coagulation and venous thrombosis 

      Grover, Steven P.; Kawano, Tomohiro; Wan, Jun; Tanratana, Pansakorn; Polai, Zsofia; Shim, Young J.; Snir, Omri; Brækkan, Sigrid Kufaas; Dhrolia, Sophia; Kasthuri, Rohan R.; Bendapudi, Pavan K.; McCrae, Keith R.; Wolberg, Alisa S.; Hansen, John Bjarne; Farkas, Henriette; Mackman, Nigel (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-11)
      C1 inhibitor (C1INH) is a multifunctional serine protease inhibitor that functions as a major negative regulator of several biological pathways, including the contact pathway of blood coagulation. In humans, congenital C1INH deficiency results in a rare episodic bradykinin-mediated swelling disorder called hereditary angioedema (HAE). Patients with C1INH deficiency–associated HAE (C1INH-HAE) have ...

    • Combined effect of high factor VIII levels and high mean platelet volume on the risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Edvardsen, Magnus; Aukrust, Pål; Ueland, Thor; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - High factor VIII (FVIII) levels and large platelets, as reflected by a high mean platelet volume (MPV), are separately associated with increased risk of venous thromboembolism (VTE). Whether the combination of high FVIII levels and large platelets has a supra-additive effect on VTE risk is unknown.<p> <p>Objectives - We aimed to investigate the joint effect of high FVIII levels and ...

    • Combined effects of plasma von Willebrand factor and platelet measures on the risk of incident venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Hindberg, Kristian; Morelli, Vania Maris; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Holtet Evensen, Line; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-06-23)
      Plasma von Willebrand factor (VWF) and platelet reactivity are risk factors for venous thromboembolism (VTE), and VWF can promote hemostasis by interaction with platelets. In this study, we explored the combined effects of plasma VWF and platelet measures on the risk of incident VTE. A population-based nested case-control study with 403 cases and 816 controls was derived from the Tromsø Study. VWF, ...

    • Complement factors B, D, C3bBbP and risk of future venous thromboembolism 

      Skjeflo, Espen Waage; Evensen, Line Holtet; Jensen, Søren Beck; Latysheva, Nadezhda; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Snir, Omri; Mollnes, Tom Eirik; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)
      The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE).<p> <p>We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of future VTE in a nested case-control study; 380 VTE patients and 804 age- and sex-matched controls derived from the Tromsø study. Odds ratios ...

    • Cross-Ancestry Investigation of Venous Thromboembolism Genomic Predictors 

      Thibord, Florian; Klarin, Derek; Brody, Jennifer A.; Chen, Ming-Huei; Levin, Michael G.; Chasman, Daniel I.; Goode, Ellen L.; Hveem, Kristian; Teder-Laving, Maris; Martinez-Perez, Angel; Aïssi, Dylan; Daian-Bacq, Delphine; Ito, Kaoru; Natarajan, Pradeep; Lutsey, Pamela L.; Nadkarni, Girish N.; de Vries, Paul S.; Cuellar-Partida, Gabriel; Wolford, Brooke N.; Pattee, Jack W.; Kooperberg, Charles; Brækkan, Sigrid Kufaas; Li-Gao, Ruifang; Saut, Noemie; Sept, Corriene; Germain, Marine; Judy, Renae L.; Wiggins, Kerri L.; Ko, Darae; O'Donnell, Christopher J.; Taylor, Kent D.; Giulianini, Franco; De Andrade, Mariza; Nøst, Therese Haugdahl; Boland, Anne; Empana, Jean-Philippe; Koyama, Satoshi; Gilliland, Thomas; Do, Ron; Huffman, Jennifer E.; Wang, Xin; Zhou, Wei; Manuel Soria, Jose; Carlos Souto, Juan; Pankratz, Nathan; Haessler, Jeffery; Hindberg, Kristian Dalsbø; Rosendaal, Frits R; Turman, Constance; Olaso, Robert; Kember, Rachel L.; Bartz, Traci M.; Lynch, Julie A.; Heckbert, Susan R.; Armasu, Sebastian M.; Brumpton, Ben Michael; Smadja, David M.; Jouven, Xavier; Komuro, Issei; Clapham, Katharine R.; Loos, Ruth J F; Willer, Cristen J.; Sabater-Lleal, Maria; Pankow, James S.; Reiner, Alexander P.; Morelli, Vania Maris; Ridker, Paul M.; Vlieg, Astrid van Hylckama; Deleuze, Jean-François; Kraft, Peter; Rader, Daniel J.; Psaty, Bruce M.; Skogholt, Anne Heidi; Emmerich, Joseph; Suchon, Pierre; Rich, Stephen S.; Vy, Ha My T; Tang, Weihong; Jackson, Rebecca D.; Hansen, John Bjarne; Morange, Pierre-Emmanuel; Kabrhel, Christopher; Trégouët, David-Alexandre; Damrauer, Scott M.; Johnson, Andrew D.; Smith, Nicholas L. (Journal article; Tidsskriftartikkel, 2022)
      <p><i>Background:</i> Venous thromboembolism (VTE) is a life-threatening vascular event with environmental and genetic determinants. Recent VTE genome-wide association studies (GWAS) meta-analyses involved nearly 30 000 VTE cases and identified up to 40 genetic loci associated with VTE risk, including loci not previously suspected to play a role in hemostasis. The aim of our research was to expand ...

    • Diagnostic Blood Biomarkers for Acute Pulmonary Embolism: A Systematic Review 

      Wikan, Vårin Eiriksdatter; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Brodin, Ellen Elisabeth; Brækkan, Sigrid Kufaas; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-06)
      (1) Background: The current diagnostic algorithm for acute pulmonary embolism (PE) is associated with the overuse of CT pulmonary angiography (CTPA). An additional highly specific blood test could potentially lower the proportion of patients with suspected PE that require CTPA. The aim was to summarize the literature on the diagnostic performance of biomarkers of patients admitted to an emergency ...

    • Effect of lower-leg trauma and knee arthroscopy on procoagulant phospholipid-dependent activity 

      Touw, Carolina E.; Nemeth, Banne; Lijfering, Willem M.; van Adrichem, Raymond A.; Wilsgård, line; Latysheva, Nadezhda; Ramberg, Cathrine; Nelissen, Rob G. H. H.; Hansen, John Bjarne; Cannegieter, Suzanne C. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-06-08)
      Background: Lower-leg injury and knee arthroscopy are both associated with venous thromboembolism (VTE). The mechanism of VTE in both situations is unknown, including the role of procoagulant microparticles. This may provide useful information for individualizing thromboprophylactic treatment in both patient groups.<p> <p>Objective: We aimed to study the effect of (1) lower-leg trauma and (2) ...

    • Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Rinde, Fridtjof Balteskard; Edvardsen, Magnus; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor; Michelsen, Annika Elisabet; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)
      <p><i>Background</i> D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. <p><i>Objectives</i> To investigate the association between plasma D-dimer levels and risk of ...

    • Elevated plasma levels of plasminogen activator inhibitor-1 are associated with risk of future incident venous thromboembolism 

      Frischmuth, Tobias; Hindberg, Kristian; Aukrust, Pål; Ueland, Thor; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-03-15)
      Background: Plasminogen activator inhibitor-1 (PAI-1), the main inhibitor of fibrinolysis, is frequently elevated in obesity and could potentially mediate the risk of venous thromboembolism (VTE) in obese subjects. However, whether PAI-1 is associated with VTE remains uncertain.<p> <p>Objective: To investigate the association between plasma PAI-1 levels and risk of future incident VTE and whether ...

    • Genetically predicted cortisol levels and risk of venous thromboembolism 

      Allarai, Elias; Lee, Wei-Hsuan; Burgess, Stephen; Larsson, Susanna C.; Lindstrom, Sara; Wang, Lu; Smith, Erin N.; Gordon, William; Van Hylckama Vlieg, Astrid; De Andrade, Mariza; Brody, Jennifer A.; Pattee, Jack W.; Haessler, Jeffrey; Brumpton, Ben Michael; Chasman, Daniel I.; Suchon, Pierre; Chen, Ming-Huei; Turman, Constance; Germain, Marine; Wiggins, Kerri L.; Macdonald, James; Brækkan, Sigrid Kufaas; Armasu, Sebastian M.; Pankratz, Nathan; Jackson, Rabecca D.; Nielsen, Jonas B; Giulianini, Franco; Puurunen, Marja K.; Ibrahim, Manal; Heckbert, Susan R.; Bammler, Theo K.; Frazer, Kelly A.; Mccauley, Bryan M.; Taylor, Kent; Pankow, James S.; Reiner, Alexander P.; Gabrielsen, Maiken Elvestad; Deleuze, Jean-Francois; O'Donnell, Chris J.; Kim, Jihye; Mcknight, Barbara; Kraft, Peter; Hansen, John Bjarne; Rosendaal, Frits Richard; Heit, John A.; Psaty, Bruce M.; Tang, Weihong; Kooperberg, Charles; Hveem, Kristian; Ridker, Paul M.; Morange, Pierre-Emmanuel; Johnson, Andrew D.; Kabrhel, Christopher; Alexandretrégouët, David; Smith, Nicholas L. (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-19)
      Introduction - In observational studies, venous thromboembolism (VTE) has been associated with Cushing’s syndrome and with persistent mental stress, two conditions associated with higher cortisol levels. However, it remains unknown whether high cortisol levels within the usual range are causally associated with VTE risk. We aimed to assess the association between plasma cortisol levels and VTE risk ...

    • Hand grip strength and risk of incident venous thromboembolism: The Tromsø study 

      Leknessund, Oda; Morelli, Vania Maris; Strand, Bjørn Heine; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-04)
      <p><b> Background</b> Hand grip strength (HGS), a common proxy of whole-body muscular strength, is associated with a wide range of adverse health outcomes and mortality. However, there are limited data on the association between HGS and risk of venous thromboembolism (VTE). <p><b> Objectives</b> We aimed to investigate the association between HGS and risk of incident VTE in a population-based ...

    • Hand grip strength in venous thromboembolism: risk of recurrence and mortality 

      Leknessund, Oda; Morelli, Vania Maris; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-06-29)
      Background - There is limited information on the relationship between muscle strength and recurrence and mortality after incident venous thromboembolism (VTE).<p> <p>Objectives - To investigate whether weak hand grip strength (HGS) was associated with risk of recurrence and mortality in patients with VTE recruited from the general population.<p> <p>Methods - Participants from the Tromsø Study ...

    • High Levels of Complement Activating Enzyme MASP-2 Are Associated With the Risk of Future Incident Venous Thromboembolism 

      Damoah, Christabel Esi; Snir, Omri; Hindberg, Kristian Dalsbø; Garred, Peter; Ludviksen, Judith K; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Mollnes, Tom Eirik; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-21)
      Background: Experimental studies have shown that the complement activating enzyme MASP-2 (mannose-binding lectin associated serine protease 2) exhibits a thrombin-like activity and that inhibition of MASP-2 protects against thrombosis. In this study, we investigated whether plasma MASP-2 levels were associated with risk of future venous thromboembolism (VTE) and whether genetic variants linked to ...

    • High plasma levels of C1-inhibitor are associated with lower risk of future venous thromboembolism 

      Grover, Steven P.; Snir, Omri; Hindberg, Kristian Dalsbø; Englebert, Tatianna M.; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Jensen, Søren Beck; Wolberg, Alisa S.; Mollnes, Tom Eirik; Ueland, Thor; Mackman, Nigel; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)
      Background - C1-inhibitor (C1INH) is a broad-acting serine protease inhibitor with anticoagulant activity. The impact of C1INH plasma levels within the normal physiological range on risk of venous thromboembolism (VTE) is unknown. We assessed the association of plasma C1INH levels and VTE risk and evaluated the impact of C1INH on thrombin and plasmin generation in ex vivo assays.<p> <p>Methods - ...

    • Impact of the von Willebrand factor-ADAMTS-13 axis on the risk of future venous thromboembolism 

      Edvardsen, Magnus; Hansen, Ellen-Sofie; Ueland, Thor; Aukrust, Pål; Brækkan, Sigrid Kufaas; Morelli, Vania Maris; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-01)
      Background - von Willebrand factor (VWF) and its cleaving protease, ADAMTS-13, form a pivotal axis that regulates hemostasis. However, the role of the VWF-ADAMTS-13 axis in the risk of future venous thromboembolism (VTE) is unknown.<p> <p>Objectives - To investigate whether plasma ADAMTS-13 levels and an imbalance with VWF levels, assessed as the VWF/ADAMTS-13 ratio, are associated with the risk ...

    • The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension 

      Jørgensen, Helle; Horváth-Puhó, Erzsébet; Laugesen, Kristina; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Sørensen, Henrik Toft (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-14)
      Background: Venous thromboembolism (VTE) is associated with increased risk of disability pension. How socioeconomic status (SES) impacts the risk of disability pension after a VTE is unknown. The aim of this nationwide population based cohort study to investigate the interaction between SES and incident VTE on the risk of subsequent disability pension.<p> <p>Methods: Using Danish national medical ...

    • The Interaction Between Venous Thromboembolism and Socioeconomic Status on the Risk of Disability Pension 

      Jørgensen, Helle; Horvath-Puho, Erzsebet; Laugesen, Kristina; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Sørensen, Henrik Toft (Journal article; Tidsskriftartikkel; Peer reviewed, 2022)
      <p><b> Background: </b>Venous thromboembolism (VTE) is associated with increased risk of disability pension. How socioeconomic status (SES) impacts the risk of disability pension after a VTE is unknown. The aim of this nationwide population based cohort study to investigate the interaction between SES and incident VTE on the risk of subsequent disability pension. <p><b> Methods:</b> Using Danish ...

    • Joint Effect of Multiple Prothrombotic Genotypes and Mean Platelet Volume on the Risk of Incident Venous Thromboembolism 

      Jakobsen, Lisa; Frischmuth, Tobias; Brækkan, Sigrid Kufaas; Hansen, John Bjarne; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-31)
      Background - A high mean platelet volume (MPV), a marker of increased platelet reactivity, is a risk factor for venous thromboembolism (VTE). Whether established prothrombotic single nucleotide polymorphisms (SNPs) further increase the VTE risk in subjects with high MPV because of biological interaction remains unknown.<p> <p>Aim - To investigate the joint effect of high MPV and prothrombotic ...

    • Joint effect of myocardial infarction and obesity on the risk of venous thromboembolism: The Tromsø Study 

      Sejrup, Joakim Knutsen; Tøndel, Birgitte Gladsø; Morelli, Vania Maris; Løchen, Maja-Lisa; Njølstad, Inger; Mathiesen, Ellisiv B.; Wilsgaard, Tom; Hansen, John Bjarne; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-19)
      Background: Myocardial infarction (MI) is associated with an increased risk of venous thromboembolism (VTE). Obesity is a recognized risk factor for both MI and VTE. Whether obesity further increases the risk of VTE in MI patients is scarcely investigated.<p> <p>Aim: To study the joint effect of MI and obesity on the risk of VTE. <p>Methods: Study participants (n = 29 410) were recruited from ...

    • Low D-dimer levels at diagnosis of venous thromboembolism are associated with reduced risk of recurrence: data from the TROLL registry 

      Rinde, Fridtjof Balteskard; Jørgensen, Camilla Tøvik; Pettersen, Heidi Hassel; Hansen, John Bjarne; Ghanima, Waleed; Brækkan, Sigrid Kufaas (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-31)
      Background: Venous thromboembolism (VTE) is a frequent disease with a high risk of recurrence. It has been suggested that the D-dimer level at the time of VTE diagnosis can be used to identify patients at a low risk of recurrence. Objectives: We aimed to investigate the impact of D-dimer levels measured at the time of VTE diagnosis on the risk of recurrence in a large cohort of patients with a ...